منابع مشابه
Lymphoid tissue inducer cells
A model for other countries? Politicians and concerned citizens in other countries will observe Germany’s movements closely, as it is the first example of a high technology country turning its back on nuclear energy after using it for more than half a century. Around the world, many old and new users of nuclear reactors are sticking to their plans and policies, only adding a safety inspection h...
متن کاملLymphoid tissue inducer cells in intestinal immunity.
During fetal development, lymphoid tissue inducer cells (LTis) seed the developing lymph node and Peyer's patch anlagen and initiate the formation of both types of lymphoid organs. In the adult, a similar population of cells, termed lymphoid tissue inducer-like cells (LTi-like cells), supports the formation of organized gut-associated lymphoid tissue (GALT) in the intestine, including both isol...
متن کاملCutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue.
Phylogeny shows that CD4 T cell memory and lymph nodes coevolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR)γ-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian lymph nodes. In this study, we show that although primary CD4 T cell expansion is normal in RORγ-deficient mice, the persistence of memory CD4 T cells is RORγ-dependent. Further...
متن کاملRoles of Embryonic and Adult Lymphoid Tissue Inducer Cells in Primary and Secondary Lymphoid Tissues
The nomenclature "embryonic lymphoid tissue inducer (LTi) cell" reflects the fundamental role of the cell in secondary lymphoid tissue organization. In addition, it is equally important in primary lymphoid tissue development as it regulates central tolerance to self-antigens in the thymus. An adult LTi cell constitutively expresses two sets of tumor necrosis factor (TNF) family members, whereas...
متن کاملLymphoid Tissue Inducer Cells: Pivotal Cells in the Evolution of CD4 Immunity and Tolerance?
PHYLOGENY SUGGESTS THAT THE EVOLUTION OF PLACENTATION IN MAMMALS WAS ACCOMPANIED BY SUBSTANTIAL CHANGES IN THE MAMMALIAN IMMUNE SYSTEM: in particular lymph nodes and CD4 high affinity memory antibody responses co-evolved during the same period. Lymphoid tissue inducer cells (LTi) are members of an emerging family of innate lymphoid cells (ILCs) that are crucial for lymph node development, but o...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2011
ISSN: 0960-9822
DOI: 10.1016/j.cub.2011.03.022